APIC-A2M - CAREstream Physician Regenerative Network
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APIC-A2M: A Non-Surgical Therapy for Osteoarthritis and Inflammation

Wouldn’t it be great to wake up in the mornings without stiffness and pain in your arthritic joints? Or to take your dog for a long walk without worrying about “paying for it” the next day?


For the majority of people with pain, their arthritic joint or disc space houses more destructive enzymes than the body can handle. Alpha-2-Macroglobulin, more commonly referred to as A2M, is our body’s own defense mechanism, but it too big and complex to enter the joint or disc space in large enough quantities. As a result, it is necessary to inject additional concentrated A2M into the affected area to restore balance and relieve pain.


If you or a loved one suffers from debilitating disease you know how devastating OA can be, and what an incredible breakthrough A2M is!

It’s estimated that approximately 27 million American adults suffer from some form of osteoarthritis (OA). With the aging Baby Boomer population combined with the obesity epidemic, OA incidence is expected to rise significantly over the next decade.

OA is a type of joint disease that results in the breakdown and destruction of cartilage – the connective tissue located between the bones of your joints that helps maintain smooth and painless movement.

Damage to cartilage happens mechanically through physical damage, as well as biochemically. Enzymes in your body – called proteases –accelerate the breakdown of your cartilage and are difficult to remove from your joints. In addition, this type of damage is very challenging for your body to repair or restore naturally because cartilage is “avascular” – meaning it doesn’t have a blood supply to provide vital proteins, growth factors and cells for tissue regeneration.

Arthritis is a general term used for conditions that cause joint pain, stiffness, swelling, and other joint symptoms. Osteoarthritis (OA) is the most common type of arthritis. In joints with OA, the protective cartilage between bones starts to wear away. This allows the bones to rub together, which can cause pain and stiffness

Orthopedic research has identified the culprit responsible for the cartilage breakdown associated with OA... Proteases. Proteases is a destructive enzyme that exists in the joint or disc space of an arthritic joint or disc.

Research has identified a natural solution for removing these destructive Proteases, Alpha 2 Macroglobulin, A2M. A2M is a preexisting molecule that can be found in your blood produced naturally by your liver to remove proteases associated with cartilage cell and tissue breakdown within the joint or disc space.

A2M has two binding sites that capture proteases (E) like a venus flytrap. Once captured, the bound A2M and proteases are eliminated from the joint or disc space through your body’s natural processes.

Although the A2M molecule is the body’s own defense mechanism against these enzymes, research has found that for a majority of patients with pain, the quantity of A2M found naturally in their joint or disc space is not always enough to remove the destructive proteases that are causing cartilage breakdown.

An A2M injection contains a concentrated dose 6x more than what already occurs in your blood naturally. When this level of A2M is placed directly into your joint or disc space, it can provide the necessary amount of A2M to bind and remove destructive proteases associated with cartilage cell and tissue breakdown within the joint or disc space.

A simple test performed by your doctor can help determine if you are a good candidate for A2M Therapy. This test looks for a unique biomarker in your joint or disc space that indicates the presence of destructive enzymes.

A Miracle Molecule

A2M, however, is a master protease inhibitor that already exists in your blood and acts as a powerful inhibitor of cartilage breakdown. It attaches to and removes the destructive proteins in the joint.


This special molecule works by binding to the enzymes (proteases) that degrade the cartilage cells and tissue.


A patented and proprietary filtration process has been developed that can concentrate the naturally occurring A2M molecule in your blood up to 6X! This process allows therapeutic injections in concentrated dosages that:


  • Boost natural healing by reducing the additional deterioration of cartilage
  • Support tissue growth with naturally occurring compounds from your own blood

Early Treatment = Better Recovery

A2M is an exciting advancement in orthopedic science resulting from years of osteoarthritis research. The earlier signals of joint destruction are discovered, the less invasive treatments will be. Early treatments can postpone the need the need for more aggressive and costly joint reconstruction or replacement surgery.


Catalyst makes this cutting edge therapy available to patients through their physicians. For more information on APIC-A2M, or to find a physician in your area, click here


FAC pain diagnostic.
Research has shown that an inflammatory cascade of proteins causes back and joint pain. A recently discovered, unique biomarker called Fibronectin-Aggrecan Complex (FAC) has been identified in the painful inflammation of spine discs and joints. A novel antibody diagnostic test called FAC is used to detect the presence of FAC from a fluid specimen taken from a painful back or joint location. Like most other laboratory tests, FAC must be ordered by your physician.